SNCA and multiple system atrophy: Subsequent work established reproducibility of a modified version of the same assay between laboratories with 96% inter-rater agreement of results with good sensitivity for MSA with predominant parkinsonism (18/20 results positive, giving a sensitivity of 90%) but a somewhat lower sensitivity for PD (9/13 results positive, giving a sensitivity of 69%) and interestingly only 1/20 positive results in MSA with predominant cerebellar ataxia, which could potentially be attributable to differences in α-synuclein strain, such as tissue tropism (Bargar et al., 2021a).