TARDBP and Alzheimer disease: The presence of TDP-43 co-pathology post-mortem is strongly associated with cognitive impairment in elderly patients with AD neuropathologic change, and its absence was associated with normal cognition despite similar degrees of AD pathology suggesting a role in overcoming “cognitive resilience” to AD neuropathology (Josephs et al., 2014; Buciuc et al., 2020).