PRNP and Creutzfeldt Jacob disease: Second-generation “IQ-CSF” RT-QuIC has demonstrated good performance in IPDs with a CJD phenotype also known as genetic CJD (gCJD), such as the E200K and V210I PRNP mutations, with sensitivities as high as 100% reported and there is preliminary data showing promise for olfactory mucosa RT-QuIC as well (Bongianni et al., 2017; Foutz et al., 2017; Franceschini et al., 2017; Lattanzio et al., 2017).