Application of α-synuclein RT-QuIC to submandibular gland tissue homogenate, in a post-mortem setting, achieved perfect sensitivity and specificity of 94%, in 13 autopsy-confirmed Parkinson’s disease patients, three incidental Lewy body disease patients and 16 controls (Manne et al., 2020a). This evidence concerns the gene SNCA and Lewy body dementia.