De Luca and colleagues reported the first application of α-synuclein RT-QuIC to a more accessible sample than CSF: nasal brushings, which seeded positive responses in 10/18 PD samples, 9/11 MSA samples, and only 1/6 CBD samples and 2/12 PSP samples (De Luca et al., 2019). Here, SNCA is linked to Parkinson disease.