CLOCK and Alzheimer disease: It has been reported that the DNAM epigenetic clock in the AD cortex is associated with AD neuropathological phenomena such as diffuse plaques, neuritic plaques and amyloid accumulation and is related to the decline in the overall cognitive and memory function of AD individuals (Levine et al., 2015); the higher the cortical DNAM age is, the lower the proportion of neuronal cells (Shireby et al., 2020).