Furthermore, by phosphorylating the transcription factor p-ETS1, the bs-5-YHEDA peptide reversed the transcription of SLC40A1 and upregulated ferriportin in the brains of senile mice, thus enhancing the excretion of iron accumulated in the aging brain and consequently protecting neurons and alleviating symptoms such as AD (Figure 1). Here, SLC40A1 is linked to Alzheimer disease.