MAPT and Alzheimer disease: In the AD brain, at the sub/cellular level, the dysregulation of several molecular pathways and intracellular signaling occurs, including Aβ and tau proteostasis, synaptic plasticity and homeostasis, inflammatory-immune responses, lipid and bioenergetic metabolism, and oxidative stress (Hampel et al., 2021), and their dysregulation results from a multilayer interaction among genetic, biological, and environmental factors (Castrillo and Oliver, 2016).