BIN1 and Alzheimer disease: At present, only a small number of genetic variations described as risk factors for AD, such as genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), which include ANK1, ABCA7, BIN1, and others, are associated with LOAD (Kunkle et al., 2019; Sims et al., 2020).