121 Nevertheless, oligodendrocytes and OPCs express VDR suggesting they can respond to calcitriol.121,127,132–134,266 To this end, different in vitro and in vivo studies investigated the impact of VitD treatment of oligodendrocytes and myelin in the context of multiple sclerosis (Fig. 4 and Table 1, Supplementary Table 7). This evidence concerns the gene VDR and multiple sclerosis.