MTHFR and Rare hereditary thrombophilia: The following tests were all negative or within normal limits: thrombophilia screen, D-dimer, total homocysteine, JAK 2 mutation analysis, viral serology (including hepatitis B and C and HIV serology), ANA, double-stranded DNA, ENA, ANCA, rheumatoid factor, anti-citrullinated protein antibody, urea and electrolyte, liver function, iron, B12, folate, calcium and vitamin D. She had an MTHFR homozygous polymorphism which was not of clinical significance in the context of a normal homocysteine and serum folate levels.