DENN domain containing 2C (DENND2C; CPM < 2, TPM = 14, PE = 100%), a positive regulator of GTPase activity involved in vesicle-mediated trafficking, was significantly decreased by 36% in Braak Stage III/IV compared with I/II and divergent protein kinase domain 2B (DIPK2B; CPM = 2, TPM = 117, PE = 100%), an X chromosome gene with links to autism,75 was decreased by 80% in Braak Stage III/IV compared with I/II. This evidence concerns the gene DENND2C and autism.