At least 15% of adults display NFTs in the medial temporal lobe (MTL) memory circuit characterized as Braak Stage I–II showing an age-associated elevation of tau pathology in cross-sectional health populations.13,14 Interestingly, elders with a pre-mortem clinical diagnosis of no cognitive impairment (NCI) met criteria for Braak NFT stages ranging from I–VI 15–17 suggesting NFT pathology is not necessary for cognitive impairment. Here, MAPT is linked to Cognitive impairment.