NHLRC1 and Lafora disease: In recent years, this response has been gaining relevance and it has been proposed as a target for therapeutic strategies for Lafora disease.26,31 Although the mechanism of microglial activation in Lafora disease is still unknown, it involves the accumulation of glycogen in the form of LBs in astrocytes, as we have recently demonstrated.14 Herein we show that the restoration of malin expression, even at an advanced stage of the disease, ameliorates the inflammatory response, as seen by the reduction in the activation of microglia and inflammatory genes.