Thus, we explored how reductions in the following DC functions affect COVID-19 severity: (1) DC transformation into APC, (2) APC migration toward lymph nodes, (3) and (4) CD4+T0 differentiation into Th1 and Tfh by APCL, (5) CD8+T0 differentiation into CTLL by APCL and Th1, (6) B0 differentiation into pB by APCL and Th1, and (7) IFN1 production by APCR (STAR Methods, Table 4, Models one and 2). Here, CD4 is linked to COVID-19.