CD8A and COVID-19: Thus, we explored how reductions in the following DC functions affect COVID-19 severity: (1) DC transformation into APC, (2) APC migration toward lymph nodes, (3) and (4) CD4+T0 differentiation into Th1 and Tfh by APCL, (5) CD8+T0 differentiation into CTLL by APCL and Th1, (6) B0 differentiation into pB by APCL and Th1, and (7) IFN1 production by APCR (STAR Methods, Table 4, Models one and 2).