SEMA3D and nonpapillary renal cell carcinoma: For all patients in the ccRCC cohort of TMA, the univariate Cox regression suggested that age at surgery (HR = 1.047, p=0.008), advanced tumor T stage (HR = 2.914, p < 0.001), advanced AJCC stage (HR = 7.128, p < 0.001), high Fuhrman grade (HR = 4.910, p < 0.001), large tumor maximal diameter (HR = 1.208, p=0.002), and low Sema3D expression (HR = 0.103, p=0.025) were associated with poor OS.