SEMA3D and neoplasm: In the multivariate analysis, Sema3D expression level (HR = 0.125, p=0.043) and age at surgery (HR = 1.061, p=0.004) were significantly associated with OS in localized ccRCC, while the tumor T stage (HR = 1.786, p=0.333), Fuhrman grade (HR = 2.594, p=0.071), and tumor maximal diameter (HR = 1.079, p=0.323) were not assessed as prognostic indicators of OS.