The expression levels of a total of 67 genes with necroptosis were calculated, and we identified 10 downregulated genes (ID1, BACH2, AXL, MYC, GATA3, TLR3, FLT3, KLF9, TNFRSF1A, and FAS) and 38 upregulated genes (HDAC9, DDX58, CYLD, MAPK8, CFLAR, MPG, RIPK1, TARDBP, SIRT2, BRAF, BCL2L11, OTULIN, ATRX, DIABLO, STUB, SPATA2, MLKL, MAP3K7, HAT1, FADD, ITPK1, CASP8, HSP90AA1, RNF31, HSPA4, USP22, TNFRSF21, SLC39A7, TSC1, SQSTM1, TRIM11, TRAF2, DNMT1, LEF1, PLK1, MYCN, CDKN2A, and TERT) in tumor tissue compared with normal tissue. The gene discussed is LEF1; the disease is neoplasm.