In 2018, Olaparib became the first PARPi approved by the FDA for the treatment of metastatic BC and later the same year Talazoparib was approved by both the FDA and European Medicines Agency (EMA) to treat germline BRCA mutated HER2-negative locally advanced or metastatic BC (Robson et al., 2017; Ettl et al., 2018; Litton et al., 2018; Cortesi et al., 2021). Here, ERBB2 is linked to breast cancer.