One of these promising mutants is ICOVIR-7 that also has a modified E2F1-promotor replacing the E1A-promoter in addition to an RGD-4C motif in the HI-loop of the fibre domain to enhance tumour selectivity, integrin-binding and entry into tumour cells (Nokisalmi et al., 2010). This evidence concerns the gene E2F1 and neoplasm.