NFE2L2 and acute respiratory distress syndrome: In addition, Panaxadiol (PX) derived from Panax ginseng root was utilized in LPS-induced ALI/ARDS, and the results showed that PX lessened the pathological lesions in mouse lungs, inhibiting ferroptosis by upregulating the Kelch-like ECH-associated protein 1 (KEAP1)/Nrf2/HO-1 pathway (Li et al., 2021b).