In lipopolysaccharide (LPS)-induced ALI animal models and bronchial epithelial cell lines, the levels of MDA, 4-hydroxynonenal (4-HNE), and total iron were dramatically increased, and the expression levels of SLC7A11 and GPX4 were decreased, indicating that ferroptosis was involved in LPS-induced ALI (Liu et al., 2020). This evidence concerns the gene GPX4 and acute respiratory distress syndrome.