We also explored the copy number variation (CNV) of PRGs in prostate cancer and found universal copy number changes; the CNVs of GSDMD, GSDMC, HMGB1, CHMP4C, CHMP6, and NOD1 were increased, while those of TP53, IL18, NLRP1, HBGB1, GZMA, PJVK, CASP1, CASP5, CASP4, and CHMP7 were decreased (Figure 1B). This evidence concerns the gene IL18 and Familial prostate cancer.