We also explored the copy number variation (CNV) of PRGs in prostate cancer and found universal copy number changes; the CNVs of GSDMD, GSDMC, HMGB1, CHMP4C, CHMP6, and NOD1 were increased, while those of TP53, IL18, NLRP1, HBGB1, GZMA, PJVK, CASP1, CASP5, CASP4, and CHMP7 were decreased (Figure 1B). Here, CASP5 is linked to Familial prostate cancer.