Then, we observed the relationship of PRG mRNA expression levels between tumor and normal tissues and found that the CNV-decreased PRGs, such as IL18, NLRP1, and PJVK, are highly expressed in the normal prostate tissue, while the CNV-increased PRGs, like CHMP4C, are upregulated in the tumor tissues (Figure 1D), suggesting that CNV may regulate the mRNA expression of PRGs. The gene discussed is IL18; the disease is neoplasm.