TP53 and squamous cell carcinoma: Data obtained on squamous carcinoma cells of head and neck cancers indicates that in cells with mutant p53 (loss of function of C176F and A161S), silencing of the p65 subunit of the NF-kB complex leads to activation of EMT, while on the contrary, in cells with wild-type p53 overexpression of NF-kB activates EMT (Lin et al., 2015).