CFTR and cystic fibrosis: The combinations of a potentiator plus a corrector (e.g., Orkambi and Symdeko), or a potentiator plus two types of correctors (e.g., Trikafta) have resulted in the functional synergism of CFTR leading to significant clinical improvement for over 90% of the CF patients (Wainwright et al., 2015; Taylor-Cousar et al., 2017; Middleton et al., 2019; Barry et al., 2021).