FMR1 and Turner syndrome: The most common genetic causes of POI are Turner syndrome, premutation in the fragile X messenger ribonucleoprotein 1 (FMR1) gene, somatic and X chromosome gene defects (FOXL2, eIF4ENIF1, STAG3, NR5A1, BMP15, FSHR, Gs alpha, and steroidogenic enzymes) (8).