ANXA3 and type 2 diabetes mellitus: Here, we applied the WGCNA method to analyze trait-related genes between T2DM and fracture non-union, performed biological function correlation analysis, identified the biomarker gene ANXA3, and utilized scRNA analysis to explore its role in fracture healing, and finally validated the expression level of ANXA3 with samples from patents with T2DM and fracture non-union in the local hospital.