In the last decade, somatic pathogenic variants in KCNJ5, CACNA1D, ATP1A1 and ATP2B3 genes, which are involved in maintaining intracellular ionic homeostasis and cell membrane potential, were described in aldosterone-producing adenomas (aldosteronomas). This evidence concerns the gene KCNJ5 and aldosterone-producing adenoma with seizures and neurological abnormalities.