ACE and hypertensive disorder: It is recommended to use angiotensin converting enzyme inhibitor (ACEI) and angiotensin receptor antagonist (ARB) to control hypertension in MetS patients, and this is beneficial to reduce Renin Angiotensin Aldosterone System(RAAS) activation, relieve glomerular hyperfiltration, and reduce proteinuria and hyperuricemia (122).RAAS blocker combined with exercise training can better reduce the hypertension, urine albumin-to-creatinine ratio, and serum creatinine of MetS patients (39, 123).