Elevated blood pressure and prolonged vasoconstriction play a vital role in the inward remodeling of hypertension, the reduction in vascular stiffness and collagen deposition in patients with Ang-II infusion-induced hypertension in magnetic resonance angiography (MRA) resulted from the EP1 receptor blocker SC19220 further confirmed EP1 receptor in vascular injury in hypertension (47, 48). The gene discussed is AGT; the disease is hypertensive disorder.