SOD1 and amyotrophic lateral sclerosis: SOD1 localizes at the pre- and post-synapse, while the ALS-associated mutant G93A SOD1 shows mis-localization in pre-synaptic terminals as well as at the post-synapse, impairing axonal transport and contributing to neuronal cell death (Lee et al., 2015; Bae and Kim, 2016).