PARK7 and Parkinson disease: Familial Parkinsonism is linked to mutations in a number of genes including α-synuclein, LRRK2, parkin, DJ-1, PINK1, UCHL-1, synphilin-1, and NR4A2 (Nussbaum and Polymeropoulos, 1997; Mizuno et al., 2001; Le et al., 2003; Marx et al., 2003; Healy et al., 2004; Maraganore et al., 2004; Valente et al., 2004; Rui et al., 2018).