Astrocyte-derived exosomes isolated from the plasma of AD patients through biotinylated antibodies against GLAST, exhibit enrichment of β-site amyloid precursor protein-cleaving enzyme 1 (BACE-1), γ-secretase, soluble Aβ42, soluble amyloid precursor protein (sAPPα and sAPPβ), all these crucial for the maintenance of Aβ42 production machinery (Goetzl et al., 2016). Here, SLC1A3 is linked to Alzheimer disease.