For instance, in the context of PD, it has been shown that exosomes isolated from CSF of PD patients positive for CD11b, which is an indicative of microglial origin, harbors higher levels of oligomeric α-synuclein, and can also propagate α-synuclein aggregation when added to neuronal cultures (Guo et al., 2020). This evidence concerns the gene ITGAM and Parkinson disease.