Terme et al. reported that tumor-bearing mice show higher expression levels of VEGFR-2 on Treg cells than healthy mice, and that neutralizing VEGFR-2 by specific antibodies can reduce the proportion of Tregs in the spleen of nude mice, indicating that VEGFR-2 signaling plays an important role in regulating Treg functions 65. The gene discussed is KDR; the disease is neoplasm.