VEGFA and neoplasm: Vascular endothelial growth factor (VEGF) is mainly secreted by the endothelial cells of blood vessels; however, it can also be generated by the immune cells of the TME, such as tumor-associated macrophages (TAM) 5, tumor-associated neutrophils (TAN) 6, 7, mast cells (MC) 8-10, myeloid-derived suppressor cells (MDSC) 11-13, and natural killer cells (NK) 14, 15.