The ability of cells to exhibit anchorage-independent cell growth, migration and colony formation has been shown to promote tumor cell aggressiveness in-vivo, and also utilized as a marker for in-vitro transformation 50, 51 We also showed the relationship among MCM10, DDR genes and tumor progression by both in-silico analysis in patient cohorts and ex-vivo patient sample analysis. The gene discussed is MCM10; the disease is neoplasm.