NOS1 and neuropathy: In diabetic related ED, neuropathy is one of contributory factor.36 Our studies disclosed the significancy of PC-NVs induced neurovascular regeneration on CNI-model.22 To validate that PC-NVs impacting neuronal regeneration in diabetic, we evaluated neuronal NOS (nNOS) and neurofilament-2000 (NF) expression on mouse cavernous dorsal nerve bundles.