The expression pattern of 3-ISGs biomarkers and distribution of the 3 ISGs expression levels among pan-cancer patients belonging to the CHCAMS and FUSCC cohorts were shown in Figures 7E-7H. Besides, we analyzed the different expression levels of ISGs and ULBP2, a classical legend of NK cells, between tumor and non-tumor tissue in CRC cohorts (Fig. 7I). The gene discussed is ULBP2; the disease is cancer.