The Cox regression multivariate analysis further demonstrated that NUF2 could serve as an independent prognostic factor for worse OS (Hazard Ratio (HR) = 1.020, 95% Confidence Interval (CI):1.002-1.039, p = 0.031 for tissue microarray dataset; HR = 1.280, 95% CI:1.101-1.488, p = 0.001 for TCGA dataset) and DFS (HR = 1.227, 95% CI:1.016-1.482, p = 0.034 for TCGA dataset) in ccRCC patients (Table 1). Here, NUF2 is linked to nonpapillary renal cell carcinoma.