NUF2 and neoplasm: In addition, transwell assays demonstrated that NUF2 suppression also considerably attenuated the migratory and invasive capacities of 769-P and ACHN cells, and accordingly led to an increase in the expression of E-cadherin (Figure 2C, 2D); the later as a classic marker of epithelial-mesenchymal transition, is specifically expressed in epithelial and its increased indicates the suppression of migration and invasion in tumor cell 20.