In our study, we identified C5aR+ cells including leukocytes (CD45+) and granulocytes (Gr1+, refers to Ly6C+ and Ly6G+), whereas C5aR was not detected on macrophages (F4/80+), fibroblasts (SMA+) and dendritic cells (CD11c+) (Fig. 5D), consistent with our results from flow cytometry (Fig. S1B & S1C), indicating the infiltrated granulocytes (Gr-1+) played an important role in our ovarian cancer tissues. This evidence concerns the gene ITGAX and ovarian cancer.