By immunohistochemical staining, we found a substantially decreased expression of proliferative cell marker Ki67 in Glut5 shRNA-expressed tumor cells compared to the control shRNA-expressed counterparts; in contrast, phosphorylation of STAT3 Y705, a marker for activated STAT3, could be equally detected in all groups (Figure 4D and S1C). This evidence concerns the gene STAT3 and neoplasm.