Decreased gastrin can directly lead to insufficient secretion of cholecystokinin, failure of normal contraction of the gallbladder, bile retention in the gallbladder, absorption of bile water by gallbladder epithelial cells, and viscous bile that is difficult to excrete, causing cholestasis and aggravating damage to the gallbladder mucosa and proinflammatory reactions. Here, GAST is linked to cholestasis.