KL and chronic kidney disease: Based on prior studies demonstrating beneficial and therapeutic effects of Klotho administration in CKD (23, 63–65) and our own work showing that disruption of FGF23 signaling by genetic ablation of Fgf23 or Klotho results in increased erythropoiesis (16, 17), in the present study we investigated the effect of exogenous α-Klotho in the development of renal anemia.