CACNB4 and idiopathic generalized epilepsy: Moreover, another family has two affected members with rare generalized tonic-clonic seizures and idiopathic generalized epilepsy (IGE) having non-synonymous variants c.311G>T and p.Cys104Phe in CACNB4, episodic ataxia (MIM: 613855) was reported in a family in which five members were suffered from disease along with two members showed the p. (Cys104Phe) variant were normal (15).