A well-defined physical activity intervention based on HIIT (6-months, 2 sessions/week, 60 min/session at 80–95% HRmax with active breaks at 50–60% of HRmax) showed no changes in methylation levels at RALBP1 in whole blood samples of adolescents with overweight/obesity (27). The gene discussed is RALBP1; the disease is obesity disorder.