Moreover, MMP2 and MMP9, which were reported to be downstream of SKA1 or TRPV2 in many other cancers, were found to be downregulated in ESCC cells when SKA1 or TRPV2 was knocked down by siRNAs (Figure 3M-P). The gene discussed is TRPV2; the disease is esophageal squamous cell carcinoma.