Importantly, in our previous research, we found that SIRT1 knockdown mice (SIRT1+/- mice) exhibits significant pre-eclampsia-like performances, such as hypertension, proteinuria, fetal growth restriction, kidney injury, and narrow labyrinthine layer, while the manifestations could be reversed after intraperitoneally injecting SRT2104, which is a highly selective agonist of SIRT117. Here, SIRT1 is linked to hypertensive disorder.