Cell lines harboring mutations in BRCA2 (MDA-MB-361, ZR75-30 or BT-20 with missense substitutions and BT-474 or HCC-1395 with nonsense mutations) or BRCA1 (HCC1954 with frameshift deletion according to COSMIC) showed sensitivity to treatment with abemaciclib (Supplementary Figure 3). This evidence concerns the gene BRCA2 and hepatocellular carcinoma.