Although overexpressed NDRG1 inhibited malignant behavior of GBM, including cell proliferation, colony formation, migration, and invasion, blockage of VEGFR2 inhibited all these behaviors even further, indicating that NDRG1-induced VEGFA may contribute to promoting angiogenesis and malignant behaviors in a VEGFA/VEFAR2 axis-dependent manner. The gene discussed is VEGFA; the disease is glioblastoma.