In protein level detection, it was found that the expression levels of PPARγ, podocin, and nephrin in renal tissue of mice in the DN group were decreased, accompanied by upregulated expressions of collagen IV and fibronectin; markers of renal interstitium fibrosis and the above protein expression changes were more obvious in renal tissue of mice in the DK group. The gene discussed is NPHS1; the disease is liver dysplastic nodule.