Subsequently, we assessed PAPPA, ITGA11, and RAB31 levels in ESCA samples from TCGA database using the UALCAN website (http://ualcan.path.uab.edu/cgi-bin/ualcan-res.pl), following that they were elevated in tumor tissues (P < 0.001, Figure 5(b)). This evidence concerns the gene ITGA11 and neoplasm.