SLC2A9 and gout: The effects of variants in SLC2A9 (Val253Ile, and Arg265His) are also inconsistent based on studies on gout and hyperuricemia, and further studies are required (Hollis-Moffatt et al., 2009; Tu et al., 2010; Urano et al., 2010; Reginato et al., 2012).