Rasheed et al. found that both a GCKR SNP (rs780094) and A1CF SNP (rs10821905) interact with alcohol exposure to increase the risk of gout in a European population under alcohol exposure conditions, suggesting that the involvement of GCKR and AICF in alcohol metabolism promotes the development of gout (Rasheed et al., 2017). The gene discussed is A1CF; the disease is gout.