To explore the effect of 303 mg of silybin-phospholipids complex, 10 mg of vitamin D, and 15 mg of vitamin E twice a day for 6 months in NAFLD patients carrying PNPLA3-rs738409, TM6SF2-rs58542926, and MBOAT7-rs641738 genetic variants. The gene discussed is TM6SF2; the disease is metabolic dysfunction-associated steatotic liver disease.