TIMP3 and neoplasm: Furthermore, they also observed that it was able to promote tumor growth and metastasis in RCC, since circ-CSNK1G3 was able to increase miR-181b, which inhibits several tumor suppressor genes, such as TIMP3, LATS2, NDRG2 and CYLD. A decreased TIMP3 leads to an enhanced EMT process, which promotes cancer metastasis.