This is due, in part, to over expression of both insulin-like growth factor 1 (IGF-1), that causes dysregulated cell growth, and hypoxia-inducible factors (HIF), which in turn help to generate vascular endothelial growth factor (VEGF), leading new blood vessels to grow and finally form cysts and tumors in the kidney (Latif et al., 1993; Pavlovich et al., 2003; DeVita et al., 2008). This evidence concerns the gene VEGFA and kidney neoplasm.