NLRP3 and Hyperglycemia: NLRP3 silencing or thioredoxin interacting protein (TXNIP) silencing blocked these alterations in hyperglycemia-induced RMEC and diabetic rat retinas, indicating that the TXNIP pathway mediates NLRP3 inflammasome activation and that inflammasome activation leads to inflammation in DR (Chen et al., 2017).