Epac1 (a downstream mediator of β-adrenergic receptors) agonist and/or NLRP3 siRNA can effectively reduce hyperglycemia-induced increases in TLR4, HMGB1, cleaved caspase-1, and IL-1β in RECs(Jiang et al., 2017). The gene discussed is NLRP3; the disease is Hyperglycemia.