NLRP3 silencing or thioredoxin interacting protein (TXNIP) silencing blocked these alterations in hyperglycemia-induced RMEC and diabetic rat retinas, indicating that the TXNIP pathway mediates NLRP3 inflammasome activation and that inflammasome activation leads to inflammation in DR (Chen et al., 2017). This evidence concerns the gene TXNIP and Hyperglycemia.