Moreover, inhibition of AXL decreases autocrine TGF-β signaling in hepatocellular carcinoma and impairs secretion of pro-angiogenic factors in breast cancer cells which in turn affects the function of endothelial cells in co-culture and in vivo (Reichl et al., 2015; Tanaka and Siemann, 2019). This evidence concerns the gene TGFB1 and hepatocellular carcinoma.