Although multiple studies revealed that WNK1 is involved in major cancer-related signaling pathways such as PI3K-AKT, TGF-β and NF-κB (Xu et al., 2005c; Jiang et al., 2005; Lee et al., 2007; Yan et al., 2008), little is known regarding how WNK1 contributes to cancer progression. This evidence concerns the gene AKT1 and cancer.