SLC12A5 and epilepsy: 2) preclinically, pharmacological (Sivakumaran et al., 2015; Kelley et al., 2016; Dzhala and Staley, 2020) or genetic (Woo et al., 2002; Silayeva et al., 2015; Chen et al., 2017; Kelley et al., 2018) inhibition of KCC2 activity exacerbates seizure-like activity across multiple epilepsy models.