For example, EGFR mutation was presented in plasma exosomes from lung cancer (Krug et al., 2018; Purcell et al., 2021) and cerebrospinal fluid EVs from glioblastoma (Figueroa et al., 2017), and KRAS mutation was presented in plasma exosomes from pancreatic cancer (Allenson et al., 2017) and colorectal cancer (Lucchetti et al., 2021). The gene discussed is KRAS; the disease is familial pancreatic carcinoma.