A previous study on 48 families with epilepsy with febrile seizures (FSs) identified a nonsense ADGRV1 variant in a family with two affected siblings, which provided initial clinical evidence on the association between ADGRV1 and epilepsy (Nakayama et al., 2002). This evidence concerns the gene ADGRV1 and Febrile seizure (within the age range of 3 months to 6 years).