SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: In contrast, most patients with FS and FS-related epilepsy caused by SCN1A variants, such as Dravet syndrome (Brunklaus et al., 2012) and partial epilepsy with FS plus (Liao et al., 2010), were at risk of seizure aggravation induced by sodium channel blocker AEDs.