VLGR1b, the largest full-length isoform, has a large extracellular domain, encompassing a signal peptide, seven epilepsy-associated repeats (i.e., epitempin repeats), and 35 calcium exchanger β (CalX-β) motifs (Beckmann et al., 1998; Scheel et al., 2002; Staub et al., 2002; Pons et al., 2003; McMillan and White, 2010). The gene discussed is ADGRV1; the disease is epilepsy.