In our study, strachydrine metabolites were significantly negatively correlated with KCNMA1 and DGAT2. Previous study findings have shown that DGAT2 is related to liver lipid metabolism; KCNMA1 was identified as a candidate gene for obesity by genome-wide association analysis (55). Here, KCNMA1 is linked to obesity due to melanocortin 4 receptor deficiency.