In conclusion, NFKBIA is the hub gene to regulate the expression of pro-inflammatory cytokines, chemokines, anti-apoptotic genes, anti-microbial genes, and inflammatory genes by controlling the NF-κB pathway to maintain a mild inflammatory response after infection in bovine mammary epithelial cells and mammary gland parenchyma (Figure 9B). The gene discussed is NFKBIA; the disease is infection.