Furthermore, a previous study reported that the antibiotic minocycline can partially correct the pathological phenotypes of astrocytes by specifically regulating the S100β, GFAP, inducible nitric oxide synthase and thrombospondins 1 and 2 expressions in DS astrocytes (Chen et al., 2014), which may provide a new treatment for DS. Here, THBS1 is linked to Dravet syndrome.