The importance of LH chromosome 17 (chr17) to their metabolic dysfunction has been demonstrated on multiple occasions, when LH consomic strains produced with either Brown Norway (Gilibert et al., 2008) or LN (Bilusic et al., 2004; Ma et al., 2017) chr17 replacement afforded some protection against obesity, dyslipidemia, and hypertension. The gene discussed is PLOD1; the disease is hypertensive disorder.