As presented in Figure 5A, only 13 of 30 hub genes (CCND1, VEGFA, CDC42, EZH2, NRAS, CASP3, PPP2R1A, COL1A1, WWP1, COL1A2, CUL2, COL3A1, and COL5A1) were significantly upregulated in breast cancer, indicating that they might be the potential target genes of let-7b-5p, miR-195-5p, miR-29a-3p, miR-26a-5p, and miR-26b-5p. The gene discussed is CUL2; the disease is breast cancer.