Further analysis revealed that more than half of DNMT3B/ALYREF-miRNA pairs showed positive expression correlation (51.3% for DNMT3B and 55.0% for ALYREF) in breast cancer, but only 10.1 and 25.0% pairs presented negative expression relationship for DNMT3B and ALYREF, respectively (Figure 2C). The gene discussed is DNMT3B; the disease is breast cancer.